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Retinal Degenerative Diseases [RDDs] are irreversible ocular damages categorized as retinopathies. RDDs affect about 0.05% of individuals worldwide. The degenerations of RPE cells are involved in inherited and age-related RDDs. After the invention of induced Pluripotent Stem Cells [iPSC] by Yamanaka, a promising avenue has been opened to regenerative medicine and disease modeling. Retinal pigment epithelium [RPE] degeneration related-RDDs are also affected by iPSCs. IPSC-derived RPE cells created a novel method for treating the RPE dege