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Expected final online publication date for the Annual Review of Biomedical Engineering, Volume 23 is June 2021. Please see http//www.annualreviews.org/page/journal/pubdates for revised estimates.The remarkable diversity of specialized metabolites produced by plants has inspired several decades of research and nucleated a long list of theories to guide empirical ecological studies. However, analytical constraints and the lack of untargeted processing workflows have long precluded comprehensive metabolite profiling and, consequently, th