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Our contribution provides rational guidance to deterministically design mid-IR emitting materials with specific narrow- or broadband properties.This work reveals some key factors for the design of a novel generation of selective melanocortin ligands at the MC4 receptor.Layered rare-earth hydroxides (LREHs), as a series of special lamellar compounds having a similar structure to layered double hydroxides (LDHs), are becoming a new type of catalyst materials. In this study, we have prepared a series of uniform LREH (RE = Y, La, Pr, Nd, S