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These findings were corroborated with cell viability assay and immunoblotting. We also showed estrogen receptor-positive MCF-7 cells were nonresponsive to Trametinib with minimal metabolic and viability changes. Our findings support that oncometabolites identified with RS will ultimately enable rapid drug screening in patients ensuring patients receive the most effective treatment at the earliest time point.4-Fluoro-9-anthracenecarboxylic acid (4F-9AC) is a thermally reversible (T-type) photomechanical molecular crystal. The photomechanical response