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We confirmed several known neuroprotective medicines offering Dutasteride, Enalapril, Finasteride, Haloperidol, and Oxybutynin, and we also identified neuroprotective properties of Elvitegravir. Utilizing live imaging of tetramethylrhodamine ethyl ester-labelled major cortical neurons, we unearthed that Elvitegravir, Dutasteride, and Oxybutynin attenuated the NMDA-induced break down of the mitochondrial membrane layer potential. Patch clamp electrophysiological rec