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Most Effective ADHD Medication For Adults The majority of adults report that medication helps to reduce their ADHD symptoms, so that they can concentrate, feel calm and have better relationships. Other treatment methods like psychotherapy can also be aided by medication. Adults with ADHD are most likely to benefit from stimulants. They include amphetamine and methylphenidate compounds. Adults can take short-acting drugs often throughout the day or long-acting medications that start working slowly and last 3 to 6 hours. Stimulants Stimulants are the most efficient