https://www.selleckchem.com/pr....oducts/actinomycin-d
Coronary blood flow adapts to metabolic demand ("metabolic regulation" and remains relatively constant over a range of pressure changes ("autoregulation". Coronary metabolic regulation and autoregulation are usually studied separately. We developed an intact animal experimental model to explore both regulatory mechanisms of coronary blood flow. Coronary pressure and flow-velocities were measured in four anesthetized and closed-chest pigs using an intracoronary Doppler wire. Metabolic regulation was assessed by coronary flow rese
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