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ADHD Treatment For Adults The stimulants methylphenidate and amphetamine help boost levels of certain brain chemicals. Nonstimulants, like atomoxetine and antidepressants, operate more slowly than stimulants but may also be helpful. Comorbid conditions often influence the response to ADHD medication. The most severe symptoms from any comorbid condition must be treated first. Then, the physician must monitor whether ADHD symptoms improve. Medication Adults with ADHD are most often treated with medication. There are many types of medication