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In both patients, RFD, 6MWD, OLST, and NPRS were improved by gait training with NMES compared to without NMES. Conclusion Our results suggest the potential of NMES as a treatment methodology for these two patients undergoing femoral head replacement for hip fracture.The term 'lifestyle' includes different factors that contribute to the maintenance of a good health status. Increasing evidences suggest that lifestyle factors may influence epigenetic mechanisms, such as miRNAs expression. The dysregulation of miRNAs can modify the expression