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The protocol was registered in a clinical trial registry as UMIN 000036051. There were no significant differences in serum periostin levels between pre-early and post-early adolescents. There were no differences by gender. Age and Body Mass Index were not significantly associated with serum periostin levels. Periostin levels were elevated in adolescents with allergic diseases overall compared to healthy adolescents [mean (95%CI) 41.6 (33.4, 49.7) vs. 28.6 (21.9, 35.3) ng/ml; P 0.05]. The effects of bone metabolism on serum periostin
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