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In this review, the bi-directional relationship between the gut and the vital human organs was envisaged and discussed under several headings. Furthermore, several disease symptoms were also re-visited to re-define the communication network between the gut microbes and the associated organs.Induced plant responses to herbivory are common, and we have learned a lot about the mechanisms of induced resistance and their effects on herbivore performance. We know less about their effects on herbivore behaviour and especially on spatial patter