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We demonstrate the effectiveness and applicability of this approach on a diverse range of design problems fragment linking, scaffold hopping, and proteolysis targeting chimera (PROTAC) design. As far as we are aware, this is the first molecular generative model to incorporate 3D structural information directly in the design process. The code is available at https//github.com/oxpig/DeLinker.Interregional trade can potentially extend the management of scarce resources beyond a region's territory along supply chains. Here we combined the mult