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001). No significant difference between-group was observed in BCVA, refractive cylinder, and spherical equivalent postoperatively. Big-bubble DALK is a useful and safe alternative to PK for medically uncontrolled FK. Big-bubble DALK is a useful and safe alternative to PK for medically uncontrolled FK.Aneuploidy is a widespread feature of malignant tumors that arises through persistent chromosome mis-segregation in mitosis associated with a pathological condition called chromosomal instability, or CIN. Since CIN is known to have a causal