https://www.selleckchem.com/pr....oducts/ci994-tacedin
Increasing evidence uncover the essential role of lncRNAs in bone metabolism and the association of lncRNA with genetic risk of osteoporosis. However, whether lncRNA Neat1 is involved remains largely unknown. In the present study, we found that Neat1 is induced by osteoclastic differentiation stimuli. Knockdown of Neat1 attenuates osteoclast formation whereas overexpression of Neat1 accelerates osteoclast formation. In vivo evidence demonstrated that enhanced Neat1 expression stimulates osteoclastogenesis and reduces bone mas
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