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Background Oropharyngeal administration of milk prior to gavage feeding has been shown to improve feeding tolerance in preterm infants. Objectives The aim is to study the effect of oropharyngeal administration of mother's milk (OPAMM), prior to gavage feeding, on the levels of gastrin, motilin, secretin, and cholecystokinin hormones. Methods Preterm infants ( less then 32 weeks' gestation) were randomized at a corrected gestational age of 33-34 weeks, in a crossover design, to receive 1 of 2 protocols 24 hours of OPAMM practice (applying 0.2 mL of mother's