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We evaluate the performance of our proposed MDPO compared to local-only execution and edge-only execution, experiments show that MDPO significantly reduces the total latency and improves the performance of DNN, and MDPO can adjust well to different network conditions.We describe the trend of antibiotic prescribing in out-of-hours (OOH) general practices (GP) before and during England's first wave of the COVID-19 pandemic. We analysed practice-level prescribing records between January 2016 to June 2020 to report the trends for the total