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OBJECTIVE To analyses the effectiveness of physical exercise in the treatment of chemotherapy in cervical cancer against fatigue reduction. METHOD This research used a quantitative method of quasi experimental research design with pre-test and post-test with control group design, sampling with total sampling method. The study sample consisted of 50 people with cervical cancer who underwent chemotherapy and experienced fatigue were grouped into 2 groups 25 treatment groups and 25 control group respondents. The analysis used Wilcoxon and M