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Two binding periods were distinguished according to the viscoelastic properties of CIP layer viscous binding in the initial period and elastic towards binding saturation. Results highlighted QCM-D as an effective and real-time technique to evaluate the role of extracellular proteins in contaminants removal.The presence of pharmaceutical micropollutants in water and wastewater is considered a serious environmental issue. To eliminate these pollutants, biodegradation of pharmaceuticals using enzymes such as laccase, is proposed as a gr