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04, -0.64, -0.94; 95% CI (-1.51 to -0.57, -0.95 to -0.33, -1.55 to -0.34); I2 = 76%, 62%, 85%; GRADE low, low, very low; TPC at two weeks and three months SMD = -0.94, -0.47; 95% CI (-1.69 to -0.18, -0.71 to -0.22); I2 = 81%, 0; GRADE very low, moderate; BDI at six months SMD = -0.45; 95% CI (-0.73 to -0.17); I2 = 0; GRADE moderate). There was no statistically significant effect for the TPC and BDI at the remaining time points (TPC at six months SMD = -0.89; 95% CI (-1.85 to 0.07); I2 = 91%; GRADE very low; BDI at two weeks and three mo