https://www.selleckchem.com/pr....oducts/CI-1040-(PD18
The ER stress common molecular signature SERCA2 was depressed by MPP . Moreover, MPP induced upregulation of GRP78, GRP94, CHOP, and decrease in procaspase-12 and TH. HC067047 and TRPV4 siRNA reversed MPP -induced ER stress and restored TH production. TRPV4 functions upstream of ER stress induced by MPP and holds promise as a prospective pharmacotherapy target for PD. TRPV4 functions upstream of ER stress induced by MPP+ and holds promise as a prospective pharmacotherapy target for PD. To describe the clinicopathologic featur
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