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24, p=.035, I =0%) and lower in females with CF (SMD=2.05, p.0001, I =0%). There is no significant difference between adults with CF and controls in knee extensor strength (SMD=0.25, p=.095, I =42.79%). Leg muscle atrophy and lower handgrip strength were noted. There may be a subgroup of adults with CF with knee extensor (quadriceps) weakness. Future studies are needed to better understand muscle impairments in people with CF; to explore the factors that can predict these muscle impairments; and to investigate their clinical signi
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