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Patients with EDSS 2 had significantly higher concentrations of HE4. Positive correlations were found between HE4 concentrations and age as well as between HE4 concentrations and disease duration. No significant correlations were found between HE4 concentrations and EDSS or between HE4 concentrations and ARR. The results of the study indicate a novel aspect of the HE4 protein in the pathomechanisms of MS. The results of the study indicate a novel aspect of the HE4 protein in the pathomechanisms of MS. The influenza A virus is the m