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Background Drug-eluting beads transarterial chemoembolization (DEB-TACE) has emerged as an alternative to conventional transarterial chemoembolization (cTACE) for treatment of hepatocellular carcinoma (HCC), although selection between the approaches remains controversial. Objective To compare patients with unresectable HCC treated with DEB-TACE and cTACE in terms of hepatobiliary changes on imaging and clinical complications. Methods This retrospective study included 1002 patients (871 men, 131 women; mean age, 59±12 years) from three ce