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Secondary analysis showed that patients on ESR ambulated earlier (0.6days vs 1.1, p = 0.028) and had their urinary catheter removed earlier (2.7days vs 3.9, p = 0.006) compared to non-ESR patients. ESR was associated with a significantly decreased in-hospital and 90-day post-operative opioid consumption and earlier mobilization with earlier urinary catheter removal in patients undergoing primary ASD surgery. These results demonstrate ESR's potential to improve outcomes in ASD perioperative care. 3. 3.Dissolving microneedle patch (DMNP)