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ZFP36, a RNA-binding necessary protein, decreases in lots of types of cancer and its own part in HCC remains uncertain. This research aimed to explore the root systems in which ZFP36 inhibited HCC progression and enhanced fluorouracil (5-Fu) sensitivity. We unearthed that ZFP36 was downregulated and PRC1 had been upregulated in HCC areas compared with adjacent non-tumor cells. In vitro investigation presented that ZFP36 acted as a tumor suppressor, while overexpression of PRC1 incre