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This short article is protected by copyright laws. All legal rights reserved.Positron emission tomography (dog) reporter genes (PRGs), when along with positron-emitting PET reporter probes (PRPs), are useful for monitoring certain cell populations in cell-based treatments, in transgenic animal designs, plus in xenograft tumefaction progression experiments. The actions of incorporated PRGs in targeted cells can be supervised noninvasively by PET imaging in preclinical in vivo researches and medical application