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7, adjusted R2 = 0.32, p = 0.00015). Patients seemed engaged in the consults, which was evident from the head nods, questions asked, and attention toward the pharmacist. Effective communication with patients or patient caregivers about opioid safety can be accomplished by using and modeling use of this handout and by providing structured instructions to use this handout optimally.During restricted time windows of postnatal life, called critical periods, neural circuits are highly plastic and are shaped by environmental stimuli. In several