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What Happens If ADHD is Left Untreated in Adults? Untreated ADHD can lead to a range of problems for adults. These include problems with relationships, work and mental health. Adults with untreated ADHD typically suffer from low self-esteem, as well as have a negative outlook on the world. This can cause them to feel like they are failing both at work and at home. Lack of Focus Being unable to focus at times is normal, especially after a long day at school or a