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Before OLT only 2 patients (13%) had severe disease activity. After OLT, 4 patients developed flares of the disease. These patients were successfully treated and remained in remission at the end of the posttransplant follow-up period (median= 3.76 years; range= 0.4-15.5 years). None of the patients developed colorectal cancer or underwent colectomy during 3.7 years of post-OLT follow-up. In our experience, the course of UC was not aggravated by OLT for PSC, and UC did not adversely affect patient or graft survival. In our experience, the