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Study participants were 61 7-year-old CPHIV and 46 age matched CHU (19 CHEU). We used diffusion tensor imaging (DTI) -based tractography to investigate white matter connections that link grey matter regions within RS functional networks. We found altered white matter integrity in the somatosensory, salience, default mode and motor networks of CPHIV compared to CHU. The superior temporal cortex, superior frontal cortex and putamen were affected in all four networks and have also been reported to demonstrate morphological alterations in th