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The present work aimed to look at the alternative of mGlu4 and 5-HT1A receptor cross-talk, the phenomenon which could act as a molecular basis associated with relationship of these receptor ligands noticed in behavioral researches. Methods First, in vitro scientific studies were performed to look at the pharmacological modulation of relationship associated with the mGlu4 and 5-HT1A receptors in the T-REx 293 cell range making use of SNAP- or HALO-tag