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The Istituto Superiore di Sanità (ISS) has been asked for rapid technical and scientific advice to the State and Regions during Sars-CoV-2 pandemic preparedness. An ad hoc Working Group on Scientific Literature updates (WG SL) was set up at ISS (March-May 202 to screen pre-prints and peer reviewed papers from arXiv, medRxiv, bioRxiv, and Pubmed to provide a real time knowledge and empirical evidence addressed to health-workers. The WG SL screened a total of 4,568 pre-prints and 15,590 peer reviewed papers, delivered as daily summary rep