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R2 = -H), which unveiled no selectivity to your organelles. The effect of this hydroxyl and alkoxy to intracellular organelle selectivity was further examined in a structurally associated system, by replacing a cyanine fragment in probe 2 by a benzothiazole moiety to provide a cyanine-benzothiazole crossbreed system. In the cyanine-benzothiazole hybrid system, probe 4 (with R2 = OCH3) revealed large selectivity towards intracellular lysosomes, that was similarly observed from its hydr