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Finding the Best Medication For ADHD The most frequently prescribed medication for ADHD is stimulants. Amphetamines and methylphenidates are among the most commonly prescribed stimulants. Short-acting stimulants start working within less than an hour and should be taken several times a day. Long-acting stimulants last for up to 16 hour and are taken at least once a day. Your doctor may prescribe antidepressants or other types of medication "off-label
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