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Uncontrolled inflammatory response and subsequent cardiomyocytes loss (apoptosis and pyroptosis) were closely involved in sepsis-induced myocardial dysfunction. Our previous study found that geniposide (GE) could protect against obesity-induced inflammation in murine hearts. However, the effect of GE on sepsis-related cardiac dysfunction is still unknown. Mice were exposed to lipopolysaccharide (LPS) to generate sepsis-induced myocardial dysfunction. And 50 mg/kg GE was used to treat mice for consecutive 7 days. Our results showed that