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The physicochemical transformations as well as the redox reaction-induced toxicity changes of ceria nanoparticles (CeO2 NPs) in reducing conditions is extremely lacking. Herein, the behaviors, chemical modifications and toxicity of CeO2 NPs in the presence of reduction-active ions (namely Fe2+ and S2-) were investigated, with a particular emphasis on the cytotoxicity mechanism associated with their physicochemical transformations. The presence of Fe2+ and S2- differently altered the surface properties and toxicity of CeO2 NPs. Redox react