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Objective This study aimed to analyze the determinant of parenting self-efficacy at parents of children aged 0-12 months at the talise health centre work area Palu city. Methods The research was conducted in talise health centre, the method used is cross sectional. The total sample of 149 samples that met the study criteria. Data was collected by questionnaire interviews. Analysis of data using statistical test Chi-square and logistic regression. Results There is influence of knowledge, social support, experience, temperament and fatigue o