https://www.selleckchem.com/pr....oducts/3-methyladeni
05 or 0.01). Circ_0005576 knockdown in CRC cells reduced proliferation, induced apoptosis, increased cells in the G1 phase, and decreased cells in the S phase ( 0.01 or 0.001). Circ_0005576 promoted CDK8 expression via sponging miR-874. miR-874 knockdown and CDK8 overexpression significantly reversed the inhibitory effect of circ_0005576 knockdown on CRC cells malignant phenotype ( 0.05 or 0.01). Circ_0005576 knockdown inhibited tumor growth in vivo ( 0.01). Circ_0005576 knockdown reduced CDK8, Ki67
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