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MDD was preceded by childhood internalizing and externalizing disorders; SUD, only among young women, was preceded by externalizing disorders. CONCLUSION Young women raised in a context where adversities like ethnic discrimination concentrate are at high risk for psychiatric disorders. In certain high-poverty contexts, young men may present MDD as often as women. Interventions to prevent psychiatric disorders may need to address gender-specific processes and childhood disorders. However, SUD prevention among young men may need to addres