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Results Among all chitosan oligosaccharides, the COS degrees of polymerization (DP) 4 showed anti-inflammatory activities (the activity order was chitopentaose 4). The levels of ROS/RNS had a strong relationship with cardiac parameters. Conclusions Chitoheptaose plays a myriad of cardioprotective roles in the myocarditis model via its antioxidant, anti-inflammatory, and antiapoptotic activities. Copyright © 2020 Qini Zhao et al.Atherosclerosis and its clinical complications constitute the major healthcare problems of the world popula