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Volatile organic compounds (VOCs) emitted from coal-fired flue gas of thermal power plants have reached unprecedented levels due to lack of understanding of reaction mechanisms under industrial settings. Herein, inhibition mechanisms for catalytic oxidation of o-xylene in simulated coal-fired flue gas are elucidated with in-situ and ex-situ spectroscopic techniques considering the presence of impurity components (NO, NH3, SO2, H2O). MnCe oxide catalysts prepared at Mn Ce mass ratios of 64 are demonstrated to promote 87% o-xylene oxidat