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Introduction In this study, we examined whether the self-selection of occupations of interest affects reaction times (RTs) and cognitive processing by using the Aid for Decision-making in Occupation Choice (ADOC) and event-related potentials (ERP). We also assessed the relationship of these with psychological indicators. Method We extracted 78 occupations from the ADOC in consideration of the subjects' age, and three conditions were set (1) self-selection of an interesting occupation; (2) self-selection of a disliked occupation; and (3