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Does ADHD Medication Work? If someone is prescribed ADHD medication, they are concerned about how long the treatment will last and if it will work. Here are some simple answers. Stimulants work by adjusting levels of brain chemicals that send messages about focus and activity. Dopamine, norepinephrine, and other brain chemicals are included. They are the first line of treatment for adults suffering from ADHD. 1. Stimulants Stimulants are frequently used to treat ADHD. They alter the activ