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GA did not have a significant effect on the migration profile of cells. Gallic Acid is shown to induce apoptosis in Ishikawa cells via Caspase 3 activation. We demonstrated a significantly higher IC50 level in 3D model which provide evidence to prefer 3D models in drug-test trials. The data obtained in the current study will provide a basis for further experiments to analyze the effects of GA on endometrial cancer and to develop strategies for clinical treatment. Gallic Acid is shown to induce apoptosis in Ishikawa cells via Caspase 3 acti