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Cell migration and intrusion of TNBC cells had been evaluated by wound recovery and transwell assays. Moreover, luciferase reporter assay was conducted to confirm the relationship between CD151 and miR-199a-3p. Results GPER activation treatment repressed MDA-MB-231 cell viability, proliferation, migration, invasion, angiogenesis and EMT process. The expression of E-cadherin ended up being increased, but N-cadherin, Vimentin, VEGFA, AngII and CD151 were decreased after GPER activation th