https://www.selleckchem.com/pr....oducts/leukadherin-1
Several novel mutations might be related to NA resistance. The selection pressures of NAs accelerated the development of RT mutations, especially within the functional domain. Mutations in the RT region occurred not only at classical sites, but also at other non-classical sites, which might be related to drug resistance and/or viral replication. The biological function and fitness of HBV isolates harbouring these novel mutations need further in vitro and in vivo verification experiments. The selection pressures of NAs accelerated
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