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To characterize strength asymmetries in the upper and lower extremities in persons with multiple sclerosis (PwMS) with severe disability, and examine associations between asymmetries and functional, symptomatic, and participatory outcomes. Cross-sectional. University research laboratory. 25 PwMS with Expanded Disability Status Scale scores between 6.0-8.0. Bilateral strength and asymmetry scores for muscle groups at the ankle, knee, and shoulder joints in addition to grip strength. Significant differences were observed between all contr