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01, CI [1.22-3.31]; P = .006). Conclusion During the COVID-19 pandemic, the prevalence of burnout, anxiety, and distress is high among academic otolaryngologists.Microtubule-associated protein Tau, abundant in the central nervous system (CNS), plays crucial roles in microtubule assembly and stabilization. Abnormal Tau phosphorylation and aggregation are a common pathogenic hallmark in Alzheimer's disease (AD). Hyperphosphorylation of Tau could change its conformation and result in self-aggregation, increased oxidative stress, and neuron