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The effects of miR-142-5p/212-5p overexpression on the TP53INP1 protein level and the proliferation and collagen formation of CFs were reversed by c-Myc overexpression. Moreover, overexpression of miR-142-5p/212-5p improved cardiac function and collagen formation of MI mice. CONCLUSION Overexpression of miR-142-5p/212-5p cooperatively suppress the proliferation and collagen formation after MI by regulating c-Myc/TP53INP1.Here, we comprehensively analysed the abundance, diversity, and activity of Tc1/mariner transposons in African coelacan