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58; 95% CI, 2.10-6.09; P .001). The treatment type for NSA did not differ between the groups. T2DM is an independent risk factor for NSA in patients undergoing nasal septoplasty, and the NSA risk is greater among patients with high DM severity. IV Laryngoscope, 2020. IV Laryngoscope, 2020.Epigenetic factors, such as DNA methylation, play an influential role in the development of the degenerative joint disease osteoarthritis (OA). These molecular mechanisms have been heavily studied in humans, and although OA affects several other